# Reading list

> Route 66 Peptides: studies along the oral route — The Route 66 Peptides reading list connects oral analogue design, dog absorption studies, hormone selectivity and the intravenous human record.

Chemical design, animal absorption and human outcomes occupy different shelves here.

## Oral candidate development

The [orally active secretagogue series](https://pubmed.ncbi.nlm.nih.gov/9733496/) supplies the opening dog bioavailability range. The [rat stomach experiment](https://pubmed.ncbi.nlm.nih.gov/11322495/) examines a peripheral contribution to hormone release. For the mechanics of redesign, the [NN703–ipamorelin hybrids](https://pubmed.ncbi.nlm.nih.gov/11459660/) and the [conformational-restriction study](https://pubmed.ncbi.nlm.nih.gov/12204475/) make a useful pair.

## Hormone characterizations

The [acute parent-peptide characterization](https://pubmed.ncbi.nlm.nih.gov/9849822/) establishes the selective growth-hormone result. The [NN703 paper](https://pubmed.ncbi.nlm.nih.gov/10427162/) gives the oral derivative its separate absorption and cortisol observations. Side by side, the papers slow my enthusiasm for carrying an adjective from one molecule to another.

## Clinical record

The [healthy-volunteer study](https://pubmed.ncbi.nlm.nih.gov/10496658/) describes intravenous exposure and the hormone pulse. The [bowel-resection trial](https://pubmed.ncbi.nlm.nih.gov/25331030/) supplies the meal-tolerance outcome and the short safety window. The [review of peptide-therapy safety and efficacy](https://pubmed.ncbi.nlm.nih.gov/41966639/) provides a wider caution about the human evidence.

## References

[1] Novel orally active growth hormone secretagogues https://doi.org/10.1021/jm980197u
[2] Do growth hormone-releasing peptides act as ghrelin secretagogues? https://doi.org/10.1385/endo:14:1:133
[3] Ipamorelin, the first selective growth hormone secretagogue https://pubmed.ncbi.nlm.nih.gov/9849822/
[4] Pharmacological characterisation of a new oral GH secretagogue, NN703 https://doi.org/10.1530/eje.0.1410180
[5] Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin https://doi.org/10.1016/s0960-894x(01)00345-6
[6] The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency https://doi.org/10.1016/s0223-5234(02)01370-3
[7] Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers https://pubmed.ncbi.nlm.nih.gov/10496658/
[8] Prospective, randomized, controlled, proof-of-concept study of the ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients https://pubmed.ncbi.nlm.nih.gov/25331030/
[9] Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance https://doi.org/10.1007/s40279-026-02437-0

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Route 66 Peptides is my roadside notebook of published research, an editorial project with no sales or medical advice.